|Biomedical Informatics Laboratory (Imanishi Laboratory)
Department of Molecular Life Science
Division of Basic Medical Science and Molecular Medicine
Tokai University School of Medicine
Toward creating future medicine based on genome information
By the biotechnological innovation, it is now possible to examine the entire genomes of individuals. Because our genomes determine personal variations in susceptibility to diseases and drug sensitivities, we need to develop the technology of the genome information analysis, which leads to the realization of personalized and preventive medicine in near future. We thus develop information technologies to predict personal “characteristics,” such as disease susceptibilities, by examining one’s genome sequences.
Released VaDE version 1.5. (March 27, 2015)
We released VarySysDB Disease Edition (VaDE) version 1.5.
VaDE provides “reproducibly” associated with disease risks, drug responses and other traits by comprehensively extracting information from many scientific papers. The VaDE database contains detailed information of disease-associated genomic polymorphisms that have been confirmed by multiple, independent studies for each human population. For example, users can search, show and download all the disease-associated genomic polymorphisms that are reproduced in the East Asian population. VaDE also provides functional information and linkage disequilibria of the polymorphic genomic sites. While genomic polymorphisms are being widely used in researches for predicting disease risks, our database can provide reliable sets of disease-associated genomic polymorphisms with the firm evidence.
This database project is partially supported by JSPS KAKENHI, Grant-in-Aid for Publication of Scientific Research Results (Grant Numbers 258055 and 268046) in 2013-2014.
The URL is http://bmi-tokai.jp/VaDE/.