We developed a new database of genomic polymorphisms that are “reproducibly” associated with disease risks, drug responses and other traits by comprehensively extracting information from many scientific papers, and released it as “VarySysDB Disease Edition (VaDE)”. The VaDE database contains detailed information of disease-associated genomic polymorphisms that have been confirmed by multiple, independent studies for each human population. For example, users can search, show and download all the disease-associated genomic polymorphisms that are reproduced in the East Asian population. VaDE also provides functional information and linkage disequilibria of the polymorphic genomic sites. While genomic polymorphisms are being widely used in researches for predicting disease risks, our database can provide reliable sets of disease-associated genomic polymorphisms with the firm evidence.

The VaDE database is accessible temporarily from here. Your feedback is highly appreciated and will help us to improve our database in the future.

This database project is partially supported by JSPS KAKENHI, Grant-in-Aid for Publication of Scientific Research Results (Grant Numbers 258055 and 268046) in 2013-2014.